Multi-year agreement combines AMD EPYC and Instinct technologies with Nutanix Cloud and Kubernetes platforms to power agentic AI across data center, hybrid, and edge environments.
AMD and Nutanix have announced a multi-year strategic partnership to jointly develop an open, full-stack AI infrastructure platform designed to support enterprise-grade agentic AI applications at scale. The collaboration is focused on delivering production-ready, high-performance AI solutions optimized for inference workloads across the edge, enterprise data centers, and multi-cloud environments.
The agreement aligns AMD’s silicon innovation and open software ecosystem with Nutanix’s enterprise cloud orchestration and Kubernetes capabilities. Together, the companies aim to provide organizations with greater architectural choice, deployment flexibility, and operational simplicity for AI infrastructure.
Open, Full-Stack AI Infrastructure for the Enterprise
At the core of the partnership is the optimization of Nutanix Cloud Platform and Nutanix Kubernetes Platform on AMD’s latest compute and acceleration technologies, including AMD EPYC CPUs and AMD Instinct GPUs. The integration will also incorporate the AMD ROCm software ecosystem and AMD Enterprise AI platform into Nutanix’s AI full-stack solutions.
This co-engineered approach is designed to deliver a scalable, open AI platform capable of supporting agentic AI systems, multimodel inference services, and industry-specific intelligent applications. By leveraging high-core-density compute, advanced GPU acceleration, and unified lifecycle management via Nutanix Enterprise AI, enterprises will be able to deploy open-source and commercial AI models without being locked into vertically integrated AI stacks.
The platform is intended to meet the growing demand for inference-optimized AI infrastructure as organizations shift from experimentation to production-scale AI deployments.
$150 Million Strategic Investment and Joint Engineering Collaboration
As part of the agreement, AMD will make a strategic equity investment of $150 million in Nutanix common stock at a purchase price of $36.26 per share. In addition, AMD will fund up to $100 million to support joint engineering initiatives and go-to-market collaboration aimed at accelerating adoption of the AMD- and Nutanix-powered agentic AI platform.
The equity investment is expected to close in the second quarter of 2026, subject to regulatory approvals and customary closing conditions.
Dan McNamara, Senior Vice President and General Manager of Compute and Enterprise AI at AMD, emphasized the importance of openness in enterprise AI infrastructure. He said, “Enterprise customers need the freedom to run the models and workloads that matter most to their business, without compromise. Through our partnership with Nutanix, we’re building a scalable, full-stack AI platform rooted in openness, designed to give enterprises and service providers the flexibility to innovate, extend and grow AI deployments across enterprises.”
Highlighting the shared strategic vision, Tarkan Maner, President and Chief Commercial Officer at Nutanix, said, “Our partnership with AMD reflects a shared vision for scalable, production-ready AI infrastructure. Together, we are delivering full-stack, integrated platforms optimized for inference and agentic applications across hybrid environments for enterprises and service providers.”
Advancing an Open Ecosystem for Enterprise AI
Enterprise AI is entering a phase where inference workloads dominate and open ecosystems are critical for long-term innovation. AMD continues to advocate for AI infrastructure built on open standards, interoperable frameworks, and architectural choice—key requirements for enterprises seeking to future-proof their AI investments.
The first jointly developed agentic AI platform from AMD and Nutanix is expected to reach the market beginning in late 2026. The solution will focus on delivering high-performance inference acceleration powered by AMD Instinct GPUs, scalable compute through AMD EPYC processors, and streamlined lifecycle management within Nutanix’s enterprise cloud environment.
By combining advanced silicon, open runtime software, and enterprise-grade orchestration, AMD and Nutanix are defining a new class of open AI infrastructure built specifically to support enterprise AI agents and large-scale inference workloads—without sacrificing flexibility, performance, or control.
